Fordyce spots are a relatively common benign condition characterized by tiny yellow to yellow-white macules and globoid papules distributed on the vermilion region of the lips and the buccal mucosa. Other less common locations include the glans penis or labia minora. Fordyce spots are composed of ‘free’ (i.e., not associated with hair follicles) sebaceous glands, and they probably represent a normal anatomic variant. They may present or become more prominent during puberty. Fordyce spots are asymptomatic, and treatment is unnecessary.