Xanthelasma is a group of yellowy-orange nodular patches that grow beneath the surface of the skin, around the upper and lower eyelids near the inner canthus. They accumulate cholesterol-rich fluid inside and are soft to touch.

The size of these fatty plaques can range from 2 mm to 30 mm and most of the time they tend to consolidate and multiply. Over time, the Xanthelasma continues multiplying in number, growing in volume, becomes permanent, and unfortunately do not regress on their own.

Although these are harmless and malignant, they are in many cases deformable and need to be removed.

Xanthelasma occurs mainly in middle-aged women

Women aged between 40-60 are more likely to develop Xanthelasma. However, even teenagers or elderly people cannot be excluded.

The appearance of Xanthelasma is often accompanied by high levels of lipids in the blood (hyperlipidemia). They are still more common in people with familial hypercholesterolemia (FH). This, however, is not the norm since more than 50% of those with Xanthelasma have low cholesterol, triglyceride and lipids ​​in the blood.


Additional factors ‘favouring’ the appearance and/or recurrence of Xanthelasma are smoking, obesity, high blood pressure, diabetes, abnormally high levels of lipids and high cholesterol.

Individuals with Xanthelasma have a higher risk of myocardial infarction, ischemic heart disease and atherosclerosis.

Their visual diagnosis is done by a dermatologist who will examine the skin around the eye and recommend cholesterol and triglyceride control.

Xanthelasma is a form of Xanthoma

Xanthoma develops into a small bump where it grows in volume and size and becomes nodular. It appears mainly in places where there is persistent pressure, such as in the knees, joints, tendons, elbows, palms, soles and buttocks, and can extend from 2.5 to 7.5 cm.

Xanthoma is a symptom of an underlying metabolic disease that increases blood lipids. It contains enough cholesterol for Xanthoma to occur in people who have high cholesterol from birth.

Efficient elimination with LASER CO2

At IQ-Intensive Quality Dermatology clinics, we effectively apply LASER CO2 to effectively eliminate Xanthelasma.

The LASER CO2 removal method is non-invasive, safe and painless. The LASER energy selectively aims at the target leaving the healthy areas around the perimeter intact and it also doesn’t leave any scars or marks. The application is performed by an experienced dermatologist in the comfort of the dermatological clinic and healing plus the return to normal activities are immediate.

If you belong to the high-risk group for the appearance or recurrence of Xanthelasma, you should follow the steps below:

  • Reduce cholesterol
  • Change eating habits
  • Drink light to moderate alcohol
  • Keep a healthy body weight
  • Do physical exercise
  • Limit the consumption of saturated fats
  • Stop smoking


You should visit Dermatology IQ – Intensive Quality Dermatology if:

You observe any accumulation of fat below or above your eyelids as it is very likely the beginning of Xanthoma.

About the author:

Christofer Tzermias

A top specialist in LASER and Invasive Dermatology in England (Oxford/London) and North America (New York/San Diego) and a leading pioneer in the implementation of sophisticated LASER in Greece, Dr Christofer Tzermias is also the founder of the first and most well-equipped inpatient departments of LASER Dermatology in the Athens Medical Center, Marousi, the St. Lucas Clinic of Panorama of Thessaloniki and the Balkan Clinic in Thessaloniki. He was the Director of Invasive and LASER Dermatology at the Athens Medical Center for 18 years, from 1996 to 2014 and is a writer and editor of numerous papers and publications for international and Greek scientific journals, as well as, international foreign language books. Dr Tzermias regularly participates in international and Greek conferences, as well as, giving speeches and lectures at university clinics in Greece and abroad. He accepts appointments at his state-of-the-art clinics on Vas. Sophia 49 - Athens, and 71 Kifissias Avenue in Marousi.

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E: dr.tzermias@gmail.com

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